Polímeros: Ciência e Tecnologia
https://www.revistapolimeros.org.br/article/doi/10.1590/0104-1428.20250066
Polímeros: Ciência e Tecnologia
Review Article

Application of biopolymers in hydrogels for tissue repair with bioextracts: systematic review

Otávio Soares Nascimento; Adriano Freitas de Santana; Cláudia Sampaio de Andrade Lima; Ana Cristina Silveira Martins; Ricardo Yara

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Abstract

Biomaterials engineering has evolved rapidly, with a particular emphasis on biofunctionalized hydrogels for tissue repair. This systematic review, based on PRISMA 2020 guidelines, analyzed 75 studies from the SCOPUS database, evaluating biopolymers combined with bioextracts for wound healing. Bibliometric analysis revealed a significant increase in publications from 2022 onward, with a focus on Biomaterials Engineering and Biotechnology. The most productive centers were the departments of Medical Nanotechnology, Biotechnology, and Biomedical Engineering. Among the central authors, Li, Doostan, and Karamanlioglu stood out. The most cited articles focused on antimicrobial and regenerative strategies. China leads in scientific production, followed by India and the USA. The most frequent keywords included “wound healing,” “hydrogel,” and “biocompatibility.” In vitro studies (53%) and combined in vitro/in vivo studies (43%) predominated. It is concluded that biofunctionalized hydrogels hold high therapeutic potential but require methodological standardization and clinical validation for safe application in regenerative medicine.

 

 

Keywords

biopolymers, controlled drug release, plant extracts, healing, regenerative medicine

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